The Srivastava lab is dedicated to the holistic understanding of how the epigenome affects the transcriptional processes that determine cell fate. During hematopoiesis, multipotent hematopoietic progenitor cells navigate a series of regulatory steps to transform into various cell lineages essential for optimal function. Given the pivotal role that disrupted epigenomic regulatory patterns play in the progression of leukemia, exploring the chromatin dynamics within both unsuccessful (malignant) hematopoietic differentiation and healthy, successful differentiation allows us to decipher their underlying molecular mechanisms.

Our lab focuses on the intricacies of blood cell development, with a special emphasis on dysregulation in leukemia. We pursue this approach with a combined methodology that includes epigenetic, computational, and cancer biology analysis. By using state-of-the-science multimodal single-cell technologies and sophisticated, uncertainty-aware computational models, the Srivastava lab dissects chromatin state dynamics and their aberrations during cell differentiation.