Hao Yuan Kueh, Ph.D. (University of Washington) – Hybrid Epigenetics Monthly Seminar Series

Hao Yuan Kueh, Ph.D.
Associate Professor
Department of Bioengineering
University of Washington
The Kueh Lab

Please join us on Thursday, September 12, 2024, as we welcome Dr. Hao Yuan Kueh, Associate Professor of Bioengineering at the University of Washington. Dr. Kueh will be giving a talk titled, “Understanding and engineering immune cell fate control circuits.” This event will take place in Smilow 10-146 and on zoom from 4PM – 5PM.

The immune system protects the body against a wide array of threats, ranging from viruses to bacteria to cancer.  These versatile defense capabilities are upheld by a collection of immune cell types, each of which can sense and mount responses tailored towards distinct types of threats.

The Kueh Lab seeks to elucidate how immune cells fate decisions, both to develop from stem cells, and to mount effective responses to challenges.  Immune cells utilize circuits of interacting genes and proteins to sense signals and execute cell state transitions.  To understand how these signaling and gene regulatory circuits work, we use powerful reporter systems and quantitative long-term imaging to follow circuit activity in single cells.  We also use cutting-edge single-cell genomics and genome engineering techniques to define their molecular parts and architecture, and use mathematical modeling to test and predict their functional performance.  Through this work, we aim to lay foundations to rationally program immune cells to fight cancer and other life threatening diseases.