Diana Fulmer, Emily J. Shields, Andrey Poleshko, Jonathan A. Epstein. Reorganization of H3K9me2-modified chromatin regions during mouse embryonic development. Dev Biol. 2025 Dec;528:188-203. doi: 10.1016/j.ydbio.2025.09.005. Epub 2025 Sep 17. PMID: 40972967.

Highlights

• H3K9me2-only domains (KODs) are genomic regions that are enriched for enhancers.
• KODs rearrange during embryonic development to adopt cell type-specific configurations.
• Loss of H3K9me2 at enhancers within KODs correlates with gene expression.
• KODs mark regulatory regions with distal enhancers spanning hundreds of kilobases.