Research Interest

Research in Dr. Su’s laboratory focuses on investigating the intricate mechanisms governing the gene expression in a cell type-, brain regional-, tissue- and species- specific manner and under physiological and pathological conditions.

Selected Publications

Su Y*#, Zhou Y*, Bennett ML, Li S, Carceles-Cordon M, Lu L, Huh S, Jimenez-Cyrus D, Kennedy BC, Kessler SK, Viaene AN, Helbig I, Gu X, Kleinman JE, Hyde TM, Weinberger DR, Nauen DW, Song H#, Ming GL#. A Single-Cell Transcriptome Atlas of Glia Diversity in the Human Hippocampus across the Postnatal Lifespan. Cell Stem Cell.2022 Nov 3;29(11):1594-1610.e8

Zhou Y*, Su Y*, Li S*, Kennedy BC, Zhang DY, Bond AM, Sun Y, Jacob F, Lu L, Hu P, Viaene AN, Helbig I, Kessler SK, Lucas T, Salinas RD, Gu X, Chen HI, Wu H, Kleinman JE, Hyde TM, Nauen DW, Weinberger DR, Ming GL, Song H.: Molecular landscapes of human hippocampal immature neurons across lifespan. Nature. 2022 Jul;607(7919):527-533.

Su Y, Shin J, Zhong C, Wang S, Roychowdhury P, Lim J, Kim D, Ming GL, Song H. Neuronal activity modifies the chromatin accessibility landscape in the adult brain. Nat Neurosci. 2017 Mar;20(3):476-483)

Su Y, Ming GL, Song H. DNA damage and repair regulate neuronal gene expression. Cell Res. 2015 Sep;25(9):993-4.

Guo JU*, Su Y*, Shin JH, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming GL, Song H. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci. 2014 Feb;17(2):215-22.

Hu S*, Wan J*, Su Y*, Song Q, Zeng Y, Nguyen HN, Shin J, Cox E, Rho HS, Woodard C, Xia S, Liu S, Lyu H, Ming GL, Wade H, Song H, Qian J, Zhu H. DNA methylation presents distinct binding sites for human transcription factors. Elife. 2013 Sep 3;2:e00726.

Su Y, Zhang J, Tang Y, Bi F, Liu JN. The novel function of nesfatin-1: anti-hyperglycemia. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1039-42.