Testing the super-enhancer concept
Blobel GA, Higgs DR, Mitchell JA, Notani D, Young RA. Testing the super-enhancer concept. Nat Rev Genet. 2021 Sep 3. doi: 10.1038/s41576-021-00398-w. Epub ahead of print. PMID: 34480110.
CTCF and transcription influence chromatin structure re-configuration after mitosis
Zhang H, Lam J, Zhang D, Lan Y, Vermunt MW, Keller CA, Giardine B, Hardison RC, Blobel GA. Nat Commun. 2021;12:5157. doi: 10.1038/s41467-021-25418-5.
Distinct properties and functions of CTCF revealed by a rapidly inducible degron system
Luan J, Xiang G, Gómez-García PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, Huang A, Keller CA, Giardine BM, Zhang Y, Lan Y, Lis JT, Lakadamyali M, Hardison RC, Blobel […]
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression
Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, […]
Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system
Werner MT, Wang H, Hamagami N, Hsu SC, Yano JA, Stonestrom AJ, Behera V, Zhong Y, Mackay JP, Blobel GA. J Biol Chem. 2020;295(7):1898-1914. doi: 10.1074/jbc.RA119.010679. PMID: 31792058
Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts
Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalik O, Giardine BM, Zhang Z, Keller CA, Hardison RC, Blobel GA. Blood. 2020;135(22):1957-1968. doi: 10.1182/blood.2020005058. PMID: 32268371
The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression
Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA. Blood. 2020;135(24):2121-2132. doi: 10.1182/blood.2020005301. […]
Alteration of genome folding via contact domain boundary insertion.
Zhang D, Huang P, Sharma M, Keller CA, Giardine B, Zhang H, Gilgenast TG, Phillips-Cremins JE, Hardison RC, Blobel GA. Nat Genet. 2020 Aug 31. doi: 10.1038/s41588-020-0680-8. PMID: 32868908
Chromatin structure dynamics during the mitosis-to-G1 phase transition.
Zhang H, Emerson DJ, Gilgenast TG, Titus KR, Lan Y, Huang P, Zhang D, Wang H, Keller CA, Giardine B, Hardison RC, Phillips-Cremins JE, Blobel GA. Nature. 2019;576:158-162. doi: 10.1038/s41586-019-1778-y. […]
The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells.
Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc […]