An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides Armour SM, Remsberg JR, Damle M, Sidoli S, Ho WY, Li Z, Garcia BA, Lazar MA. Nat Commun. 2017 […]
The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, […]
Histone Deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims […]
Maturing of the nuclear receptor family. Lazar MA. J Clin Invest. 2017 Apr 3;127(4):1123-1125. doi: 10.1172/JCI92949. Epub 2017 Apr 3.
Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed […]
Genetic and epigenomic mechanisms of mammalian circadian transcription. Dec 6, 2016 Papazyan R, Zhang Y, Lazar MA. Nat Struct Mol Biol. 2016 Dec 6;23(12):1045-1052. doi: 10.1038/nsmb.3324. Review.
Circadian time signatures of fitness and disease. Bass J, Lazar MA. Science. 2016 Nov 25;354(6315):994-999. Review.
Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion. Remsberg JR, Ediger BN, Ho WY, Damle M, Li Z, Teng C, Lanzillotta C, […]
Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang […]
HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms. Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA. Genes […]